Journal article
AT1 receptor antagonist treatment caused persistent arterial functional changes in young spontaneously hypertensive rats.
Abstract
The effects of chronic treatment with an AT1 receptor antagonist (L-158,809) on hypertension development and cardiovascular changes were studied in spontaneously hypertensive rats (SHR) and Wistar-Kyoto rats (WKY). L-158,809 treatment (0.6 mg/kg PO) was initiated at 3 weeks of age and lasted 12 weeks, to 15 weeks of age. The treatment prevented hypertension development in the SHR (systolic blood pressure, BP, of 136+/-1 mm Hg compared with …
Authors
Gillies LK; Lu M; Wang H; Lee RMKW
Journal
Hypertension, Vol. 30, No. 6, pp. 1471–1478
Publisher
Wolters Kluwer
Publication Date
December 1997
DOI
10.1161/01.hyp.30.6.1471
ISSN
0194-911X
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AgingAngiotensin IIAngiotensin Receptor AntagonistsAnimalsAntihypertensive AgentsBlood PressureBody WeightElectric StimulationHeartHypertensionImidazolesKidneyMaleMesenteric ArteriesMuscle, Smooth, VascularOrgan SizeRatsRats, Inbred SHRRats, Inbred WKYReceptor, Angiotensin, Type 1Receptor, Angiotensin, Type 2Tetrazoles