Journal article
Abnormal renal medullary response to angiotensin II in SHR is corrected by long-term enalapril treatment
Abstract
This study tested the hypotheses that renal medullary blood flow (MBF) in spontaneously hypertensive rats (SHR) has enhanced responsiveness to angiotensin (ANG) II and that long-term treatment with enalapril can correct this. MBF, measured by laser Doppler flowmetry in anesthetized rats, was not altered significantly by ANG II in Wistar-Kyoto (WKY) rats, but was reduced dose dependently (25% at 50 ng. kg(-1). min(-1)) in SHR. Infusion of …
Authors
Dukacz SAW; Feng M-G; Yang L-F; Lee RMKW; Kline RL
Journal
AJP Regulatory Integrative and Comparative Physiology, Vol. 280, No. 4, pp. r1076–r1084
Publisher
American Physiological Society
Publication Date
April 1, 2001
DOI
10.1152/ajpregu.2001.280.4.r1076
ISSN
0363-6119