Journal article
Effects of the KIR7.I Blocker VU590 on Spontaneous and Agonist-Induced Contractions of Human Pregnant Myometrium
Abstract
KIR7.1, an inwardly rectifying K+ channel, plays a critical role in regulating uterine excitability during pregnancy and has been suggested as a potential new target for the treatment of conditions arising from dysfunctional uterine contractility, for example, atonic postpartum hemorrhage. The aim of this study was to investigate the effects of the selective KIR7.1 blocker, VU590, on both spontaneous and agonist-stimulated contractions of human …
Authors
Crankshaw DJ; Crosby DA; Morrison JJ
Journal
Reproductive Sciences, Vol. 24, No. 10, pp. 1402–1409
Publisher
Springer Nature
Publication Date
October 2017
DOI
10.1177/1933719116687657
ISSN
1933-7191