Use of Segments for the Quality Control of the Factor VIII: Coagulant Activity of Fresh Frozen Plasma Journal Articles uri icon

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abstract

  • Abstract. The storage of fresh frozen plasma (FFP) for short periods at –20 °C for 6 weeks, –30°C for 12 weeks, or –40°C for 12 weeks, did not result in significant deterioration in factor VIII: coagulant (factor VIII:C) activity in the primary packs. In studies examining whether plasma segments could be used for quality control purposes, the mean factor VIII:C activity of the primary pack was found to be identical to that of the attached segments of plasma for units of FFP which were thawed within 2 h after preparation. This was also true for FFP units stored at –40 and –60°C for up to 12 weeks. There was, however, a loss in factor VIII:C activity in the segments of FFP units stored at either –20 or –30°C for 6 and 12 weeks, respectively. Thus for units of FFP stored at temperatures colder than –40°C, segments are suitable for assessing the factor VIII:C activity in the primary pack but not for FFP units stored at –20 or –30°C.

publication date

  • April 1985