Use of Segments for the Quality Control of the Factor VIII: Coagulant Activity of Fresh Frozen Plasma Academic Article uri icon

  •  
  • Overview
  •  
  • Research
  •  
  • Identity
  •  
  • Additional Document Info
  •  
  • View All
  •  

abstract

  • The storage of fresh frozen plasma (FFP) for short periods at -20 degrees C for 6 weeks, -30 degrees C for 12 weeks, or -40 degrees C for 12 weeks, did not result in significant deterioration in factor VIII: coagulant (factor VIII:C) activity in the primary packs. In studies examining whether plasma segments could be used for quality control purposes, the mean factor VIII:C activity of the primary pack was found to be identical to that of the attached segments of plasma for units of FFP which were thawed within 2 h after preparation. This was also true for FFP units stored at -40 and -60 degrees C for up to 12 weeks. There was, however, a loss in factor VIII:C activity in the segments of FFP units stored at either -20 or -30 degrees C for 6 and 12 weeks, respectively. Thus for units of FFP stored at temperatures colder than -40 degrees C, segments are suitable for assessing the factor VIII:C activity in the primary pack but not for FFP units stored at -20 or -30 degrees C.

publication date

  • April 1985