The Effects of Excitatory Drugs on Potassium Fluxes in Uterine Smooth Muscle Academic Article uri icon

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abstract

  • Exchange of 42K and 86Rb has been studied in pregnant rat uterine muscle. Efflux of these ions could be represented as the sum of three exponential processes, but discrimination between potassium and rubidium was observed. Acetylcholine, but not oxytocin, increased the passive permeability of the cell membrane to potassium or rubidium, as indicated by drug-induced movements of 42K or 86Rb in normal tissues and in tissues depolarized by potassium chloride medium. The implications of this difference for the excitation mechanisms of these drugs and for the possibility that spike repolarization was caused by increased potassium permeability were discussed.

publication date

  • July 1, 1972