Characteristics of Arterial Plasma Membrane in Renovascular Hypertension in Rats Journal Articles uri icon

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abstract

  • Protein content, enzymatic activites and Ca<sup>2+</sup> accumulation capacities were studied in plasma membrane fractions isolated from mesenteric arteries of rats made hypertensive by renal artery stenosis with and without contralateral nephrectomy, i.e., one-kidney, one clip (1-KHR) and two-kidney, one clip (2-KHR) hypertension, respectively. Both types of renovascular hypertension showed similar vascular plasma membrane abnormalities which included increased total protein contents, enhanced alkaline phosphatase activities and reduced ATP-dependent Ca<sup>2+</sup> accumulation compared to control values. The altered alkaline phosphatase activity and ATP-dependent Ca<sup>2+</sup> accumulation appeared to be associated with blood pressure elevation in both types of hypertension and may be related to the elevation of blood pressure insensitive to captopril (SQ 14,225) in 1-KHR and 2-KHR. These results are consistent with the current concept of biochemical abnormalities of arterial smooth muscle in the development of renovascular hypertension in rats in addition to the involvement of the renin-angiotensin system.

publication date

  • 1980