Journal article
Pharmacological study of the contractile activity of leukotriene C4 and D4 on isolated human airway smooth muscle
Abstract
Synthetic leukotriene C4(LTC4) and leukotriene D4(LTD4) were examined on isolated human tracheal and bronchial smooth muscle. Both LTC4 and LTD4 produced slowly developing contraction of trachealis and bronchus which were submaximal (70-85% of the carbachol maximum) and were not blocked by 1.0 microM atropine, 5.0 microM mepyramine, or 5.6 microM indomethacin. The EC50's for LTC4 and LTD4 were 10.3 and 1.8 nM on trachealis and 1.8 and 1.7 nM on …
Authors
Jones TR; Davis C; Daniel EE
Journal
Canadian Journal of Physiology and Pharmacology, Vol. 60, No. 5, pp. 638–643
Publisher
Canadian Science Publishing
Publication Date
May 1, 1982
DOI
10.1139/y82-087
ISSN
0008-4212