Journal article
Effect of an anti-Mo1 MAb on ozone-induced airway inflammation and airway hyperresponsiveness in dogs
Abstract
Ozone inhalation causes neutrophil migration into the airway and airway hyperresponsiveness in dogs. The leukocyte adhesion molecule Mo1 (CD11b/CD18) is a heterodimeric glycoprotein the expression of which is necessary for neutrophil adhesion to endothelium. To evaluate the contribution of Mo1 to ozone-induced neutrophil influx and airway hyperresponsiveness, six dogs were treated intravenously with an Anti-Mo1 monoclonal antibody (3.75 mg/kg …
Authors
Li Z; Daniel EE; Lane CG; Arnaout MA; O'Byrne PM
Journal
American Journal of Physiology, Vol. 263, No. 6, pp. l723–l726
Publisher
American Physiological Society
Publication Date
December 1, 1992
DOI
10.1152/ajplung.1992.263.6.l723
ISSN
0002-9513