Journal article
NK1 receptors mediated release of 6-keto-PGF1 alpha from the ex vivo perfused canine ileum.
Abstract
The purpose of this study was to determine the effects of tachykinins on prostanoid production by the dog ileum and to characterize the tachykinin receptor(s) responsible for the principal eicosanoid shown to be released, 6-keto-PGF1 alpha. Substance P, the selective NK1 receptor agonist [Sar9,Met(O2)11]substance P and neurokinin A caused concentration-dependent production of 6-keto-PGF1 alpha; neurokinin A was least potent. The selective NK2 …
Authors
Parrish MB; Rainsford KD; Johnson DM; Daniel EE
Journal
Journal of Pharmacology and Experimental Therapeutics, Vol. 271, No. 1, pp. 39–47
Publisher
Elsevier
Publication Date
October 1994
DOI
10.1016/s0022-3565(25)22703-3
ISSN
0022-3565