Journal article
Tetrandrine inhibits Ca2+ release-activated Ca2+ channels in vascular endothelial cells
Abstract
The effects of tetrandrine (TET), a Ca2+ antagonist of bis-benzylisoquinoline alkaloid origin, on cultured single bovine pulmonary artery endothelial cells were examined using fluorescence ratio imaging and whole-cell attached patch-clamp techniques. Thapsigargin (TSG, 100 nM), a selective endoplasmic reticulum Ca2+-ATPase pump inhibitor known to induce the release of nitric oxide (NO) from vascular endothelial cells via a Ca2+-dependent …
Authors
Kwan C-Y; Leung Y-M; Kwan TK; Daniel EE
Journal
Life Sciences, Vol. 68, No. 7, pp. 841–847
Publisher
Elsevier
Publication Date
January 2001
DOI
10.1016/s0024-3205(00)00988-7
ISSN
0024-3205