Journal article
Characterization of a fluorescence-signaling and RNA-cleaving deoxyribozyme.
Abstract
DNA enzymes (deoxyribozymes or DNAzymes) are single-stranded DNA molecules with catalytic function. Previously, we isolated several RNA-cleaving deoxyribozymes with fluorescence-signaling properties. These special DNA molecules are capable of cleaving an RNA linkage embedded within a DNA sequence and flanked by a pair of deoxyribothymidines modified with a fluorophore (fluorescein) and a quencher (dabcyl). Here we report on the sequence …
Authors
Shen Y; Brennan JD; Li Y
Journal
Nucleic Acids Symposium Series, Vol. 49, No. 49, pp. 55–56
Publisher
Oxford University Press (OUP)
Publication Date
September 1, 2005
DOI
10.1093/nass/49.1.55
ISSN
0261-3166