Journal article
Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity.
Abstract
Loss of telomeric DNA during cell proliferation may play a role in ageing and cancer. Since telomeres permit complete replication of eukaryotic chromosomes and protect their ends from recombination, we have measured telomere length, telomerase activity and chromosome rearrangements in human cells before and after transformation with SV40 or Ad5. In all mortal populations, telomeres shortened by approximately 65 bp/generation during the lifespan …
Authors
Counter CM; Avilion AA; LeFeuvre CE; Stewart NG; Greider CW; Harley CB; Bacchetti S
Journal
The EMBO Journal, Vol. 11, No. 5, pp. 1921–1929
Publisher
Springer Nature
Publication Date
5 1992
DOI
10.1002/j.1460-2075.1992.tb05245.x
ISSN
0261-4189