Journal article
Telomerase activity in human ovarian carcinoma.
Abstract
Telomeres fulfill the dual function of protecting eukaryotic chromosomes from illegitimate recombination and degradation and may aid in chromosome attachment to the nuclear membrane. We have previously shown that telomerase, the enzyme which synthesizes telomeric DNA, is not detected in normal somatic cells and that telomeres shorten with replicative age. In cells immortalized in vitro, activation of telomerase apparently stabilizes telomere …
Authors
Counter CM; Hirte HW; Bacchetti S; Harley CB
Journal
Proceedings of the National Academy of Sciences of the United States of America, Vol. 91, No. 8, pp. 2900–2904
Publisher
Proceedings of the National Academy of Sciences
Publication Date
April 12, 1994
DOI
10.1073/pnas.91.8.2900
ISSN
0027-8424