Journal article
Alternative Lengthening of Telomeres Is Characterized by High Rates of Telomeric Exchange
Abstract
Telomere maintenance activity is a hallmark of cancer. In some telomerase-negative tumors, telomeres become lengthened by alternative lengthening of telomeres (ALT), a recombination-mediated DNA replication process in which telomeres use other telomeric DNA as a copy template. Using chromosome orientation fluorescence in situ hybridization, we found that postreplicative exchange events involving a telomere and another TTAGGG-repeat tract occur …
Authors
Londoño-Vallejo JA; Der-Sarkissian H; Cazes L; Bacchetti S; Reddel RR
Journal
Cancer Research, Vol. 64, No. 7, pp. 2324–2327
Publisher
American Association for Cancer Research (AACR)
Publication Date
April 1, 2004
DOI
10.1158/0008-5472.can-03-4035
ISSN
0008-5472