Transforming growth factor‐β and epidermal growth factor modulate basal and interleukin‐6‐induced amino acid uptake and acute phase protein synthesis in cultured rat hepatocytes Journal Articles uri icon

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abstract

  • Rat hepatocytes cultured for 2 days with interleukin‐6 show increased synthesis of acute phase proteins and enhanced accumulation of 14C‐labelled α‐aminoisobutyric acid. Transforming growth factor‐β1 (0.1–10 ng/ml) inhibits whereas epidermal growth factor (1–100 ng/ml) enhances both basal and interleukin‐6‐induced amino acid uptake by rat hepatocytes with only a slight alteration of acute phase protein synthesis.

publication date

  • June 18, 1990