Journal article
Proteoglycans decorin and biglycan differentially modulate TGF-β-mediated fibrotic responses in the lung
Abstract
Transforming growth factor (TGF)-beta is a key cytokine in the pathogenesis of pulmonary fibrosis, and pharmacological interference with TGF-beta can ameliorate the fibrotic tissue response. The small proteoglycans decorin and biglycan are able to bind and inhibit TGF-beta activity in vitro. Although decorin has anti-TGF-beta properties in vivo, little is known about the physiological role of biglycan in vivo. Adenoviral gene transfer was used …
Authors
Kolb M; Margetts PJ; Sime PJ; Gauldie J
Journal
American Journal of Physiology - Lung Cellular and Molecular Physiology, Vol. 280, No. 6, pp. l1327–l1334
Publisher
American Physiological Society
Publication Date
June 1, 2001
DOI
10.1152/ajplung.2001.280.6.l1327
ISSN
1040-0605
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AdenoviridaeAnimalsBiglycanBronchoalveolar Lavage FluidCell LineDecorinDose-Response Relationship, DrugExtracellular Matrix ProteinsFemaleFibroblastsGene Transfer TechniquesGenetic VectorsHumansHydroxyprolineImmunohistochemistryLungMiceMice, Inbred C57BLProteoglycansPulmonary FibrosisTissue DistributionTransforming Growth Factor betaTreatment Outcome