Fragmin in Unstable Angina Pectoris or in Non-Q-Wave Acute Myocardial Infarction (the FRIC Study) Journal Articles uri icon

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  • The safety and efficacy of weight-adjusted, low-molecular-weight heparin (dalteparin) was compared with that of unfractionated heparin during 6 days of treatment in 1,482 patients with unstable angina or non-Q-wave myocardial infarction. Dalteparin, at a lower dose, was compared with placebo during the following 39 days. No significant outcome difference was found between the 2 treatment regimens in the unblinded phase (days 1-6). Between days 6-45 the rates of death, myocardial infarction, and recurrence of angina were comparable between the active treatment and placebo groups. The results suggest that twice-daily administration of subcutaneous dalteparin may be an effective and safe alternative to unfractionated heparin during the acute phase of unstable coronary artery disease. Prolonged treatment with dalteparin at a lower once-daily dose did not confer any additional benefit over aspirin (75-165 mg) alone.


  • Klein, Werner
  • Buchwald, Arnd
  • Hillis, W Stewart
  • Monrad, Scott
  • Sanz, Ginés
  • Turpie, Alexander Graham Gri
  • van der Meer, Jan
  • Olaisson, Eric
  • Undeland, Sven
  • Ludwig, Karin

publication date

  • September 1997