Journal article
Strategies for ocular siRNA delivery: Potential and limitations of non-viral nanocarriers
Abstract
Controlling gene expression via small interfering RNA (siRNA) has opened the doors to a plethora of therapeutic possibilities, with many currently in the pipelines of drug development for various ocular diseases. Despite the potential of siRNA technologies, barriers to intracellular delivery significantly limit their clinical efficacy. However, recent progress in the field of drug delivery strongly suggests that targeted manipulation of gene …
Authors
Thakur A; Fitzpatrick S; Zaman A; Kugathasan K; Muirhead B; Hortelano G; Sheardown H
Journal
Journal of Biological Engineering, Vol. 6, No. 1,
Publisher
Springer Nature
Publication Date
December 2012
DOI
10.1186/1754-1611-6-7
ISSN
1754-1611