Journal article
Sulfadiazine modified PDMS as a model material with the potential for the mitigation of posterior capsule opacification (PCO)
Abstract
Cataract surgery, while the most common surgical procedure performed, leads to posterior capsule opacification in approximately 30% of cases. Transforming growth factor beta 2 (TGF-β2) and matrix metalloproteinases (MMPs) have been shown to play important roles in the cellular processes leading to posterior capsule opacification. Delivery of inhibitors to MMPs may have the potential to inhibit the initial cascade of events that lead to PCO. …
Authors
Amoozgar B; Morarescu D; Sheardown H
Journal
Colloids and Surfaces B Biointerfaces, Vol. 111, , pp. 15–23
Publisher
Elsevier
Publication Date
11 2013
DOI
10.1016/j.colsurfb.2013.05.002
ISSN
0927-7765
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
ActinsCapsule OpacificationCell CommunicationCell LineCell MovementCell SurvivalCollagenDimethylpolysiloxanesFibronectinsHumansInfantLamininLens, CrystallineMass SpectrometryPhotoelectron SpectroscopyPolyethylene GlycolsSpectroscopy, Fourier Transform InfraredSulfadiazineSurface PropertiesWaterrho GTP-Binding Proteins