Sex-Based Differences in the Effect of Intra-Arterial Treatment of Stroke Academic Article uri icon

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  • BACKGROUND AND PURPOSE: Sex influences outcome after intravenous thrombolysis. In a combined analysis of the tissue plasminogen activator clinical trials, a sex-by-treatment interaction was observed. We sought to confirm that observation in an independent data set. METHODS: Data were from the Pro-Urokinase for Acute Cerebral Thromboembolism-2 (PROACT-2) trial. Baseline factors were compared by sex. The primary outcome was an assessment of a sex-by-treatment interaction term within a logistic regression model, using a modified Rankin Scale score


  • Hill, Michael D
  • Kent, David M
  • Hinchey, Judith
  • Rowley, Howard
  • Buchan, Alastair M
  • Wechsler, Lawrence R
  • Higashida, Randall T
  • Fischbein, Nancy J
  • Dillon, William P
  • Gent, Michael
  • Firszt, Carolyn M
  • Schulz, Gregory A
  • Furlan, Anthony J

publication date

  • September 2006

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