Depressed herpes simplex virus-induced lymphocyte blastogenesis in individuals with severe recurrent herpes infections

Studies of lymphocyte blastogenesis were carried out on two children with demonstrated unusual susceptibility to recurrent herpes infections and on twenty volunteers suffering from recurrent cold sores. Depressed responses were observed in the two children as well as their parents and in five individuals with a high frequency of clinical disease (greater than six attacks per year). There was a significantly greater blastogenic response during …