Journal article
T Lymphocytes in Genital Lymph Nodes Protect Mice from Intravaginal Infection with Herpes Simplex Virus Type 2
Abstract
Herpes simplex virus type 2 (HSV-2) is a human venereal pathogen that causes lethal neurological illness after intravaginal inoculation into BALB/cJ mice. Intravaginal vaccination of mice with an attenuated strain of HSV-2 rapidly induces immunity to a lethal intravaginal challenge with wild-type HSV-2. This resistance is transferrable to syngeneic mice with genital lymph node (GLN) cells but not with cells from other lymphoid sources. Here we …
Authors
McDermott MR; Goldsmith CH; Rosenthal KL; Brais LJ
Journal
The Journal of Infectious Diseases, Vol. 159, No. 3, pp. 460–466
Publisher
Oxford University Press (OUP)
Publication Date
March 1, 1989
DOI
10.1093/infdis/159.3.460
ISSN
0022-1899