BLISS index for analyzing knee osteoarthritis trials data Academic Article uri icon

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  • OBJECTIVES: Different pain thresholds were investigated, using the WOMAC Pain Scale (WOMAC-P) to determine if they could differentiate between treatment groups (hylan G-F 20 vs. appropriate care) at low and very low levels of state attainment in patients with knee osteoarthritis (OA). A method, termed the BLISS (Bellamy et al. Low Intensity Symptom State-attainment) Index, for analyzing OA knee clinical trials data, was proposed. STUDY DESIGN AND SETTING: Five analyses were performed: time to first BLISS day, BLISS days over 12 months, patients with a BLISS response at month 12, patients with a BLISS response at any time, and number of BLISS periods over 12 months. For each analysis, five levels of WOMAC-P were examined:


  • Bellamy, Nicholas
  • Bell, Mary J
  • Pericak, Dan
  • Goldsmith, Charles Harry
  • Torrance, George W
  • Raynauld, Jean-Pierre
  • Walker, Valery
  • Tugwell, Peter
  • Polisson, Richard

publication date

  • February 2007