Dystrophic Spinal Cord Transplants Induce Abnormal Thymidine Kinase Activity in Normal Muscles

The role of the neural tube in the pathogenesis of muscular dystrophy was tested directly. Neural tubes from chicken embryos with hereditary muscular dystrophy and from genetically normal embryos were transplanted into normal recipient embryos. Dystrophic neural tissue induced in muscles of normal hosts high thymidine kinase activity characteristic of dystrophic muscle; normal neural tubes did not. We propose an early inductive effect of the neural tube on the presumptive myoblasts that sets their subsequent course of development, either normal or dystrophic.