Evidence for a selective stimulation of myosin synthesis following muscle denervation

The incorporation of radioactive leucine into newt triceps muscle was measured at intervals up to 24 hr following denervation of the muscle. Incorporation, measured either by total acid-precipitable radioactivity or summation of activity in fractions obtained by disc gel electrophoresis of muscle proteins, was initially stimulated by up to 70% for a period of up to 12 hr after denervation. Subsequently, the incorporation fell below that found …