Journal article
Rat astroglial P2Z (P2X7) receptors regulate intracellular calcium and purine release
Abstract
Treatment of rat astrocyte cultures with 2'- and 3'-O-(4-benzoylbenzoyl)-adenosine 5'-triphosphate (BzATP), a P2X7 agonist, but not with adenosine 5-[alpha, beta methylene] triphosphate (alpha, beta meATP), a P2X agonist, increased influx of extracellular Ca2+ and [Ca2+]i. Lucifer yellow, a small molecule which permeates P2X7 receptor-induced pores, entered BzATP-treated but not control astrocytes. BzATP also stimulated efflux of [3H]purine …
Authors
Ballerini P; Rathbone MP; Di Iorio P; Renzetti A; Giuliani P; D'Alimonte L; Trubiani O; Caciagli F; Ciccarelli R
Journal
Neuroreport, Vol. 7, No. 15, pp. 2533–2538
Publisher
Wolters Kluwer
Publication Date
November 1996
DOI
10.1097/00001756-199611040-00026
ISSN
0959-4965