Journal article
Dependence of the porphyrogenic effect of 2,3,7,8-tetrachlorodibenzo(p)dioxin upon inheritance of aryl hydrocarbon hydroxylase responsiveness
Abstract
Experimental porphyria caused by chlorinated aromatic hydrocarbons is associated with decreased uroporphyrinogen decarboxylase activity and induction of the microsomal mixed function oxygenase systems, especially cytochrome P1-450 (P-448). 2,3,7,8-Tetrachlorodibenzo(p)dioxin (TCDD) produces porphyria in mice and is a specific inducer of cytochrome P1-450 and its associated aryl hydrocarbon hydroxylase (AHH) activity. To test the hypothesis that …
Authors
Jones KG; Sweeney GD
Journal
Toxicology and Applied Pharmacology, Vol. 53, No. 1, pp. 42–49
Publisher
Elsevier
Publication Date
March 1980
DOI
10.1016/0041-008x(80)90379-8
ISSN
0041-008X