Journal article
Sensitivity to suppression of cytotoxic T cell generation by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is dependent on the Ah genotype of the murine host
Abstract
Susceptibility of mice to a variety of toxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is genetically determined by the Ah locus. To determine if immunotoxicity following TCDD exposure was also regulated by the Ah locus, we tested the ability of low dose TCDD (4 ng/kg) to suppress the generation of allospecific cytotoxic T cells (CTL) by lymphocytes from "susceptible" C57B1/6, and "resistant" DBA/2, and from C57B1/6XDBA/2J F1 hybrid …
Authors
Nagarkatti PS; Sweeney GD; Gauldie J; Clark DA
Journal
Toxicology and Applied Pharmacology, Vol. 72, No. 1, pp. 169–176
Publisher
Elsevier
Publication Date
January 1984
DOI
10.1016/0041-008x(84)90261-8
ISSN
0041-008X