Journal article
Interaction of human lactoferrin with the rat liver
Abstract
Binding of human lactoferrin (hLf) by purified rat liver plasma membranes was studied to clarify whether the liver possesses specific hLf receptors. The binding was rapid between 4 degrees and 37 degrees C, with a pH optimum close to 5.0. At 22 degrees C and in glycine-NaOH (5 mM, pH 7.4) containing 150 mM NaCl and 0.5% albumin, 1 microgram of membrane bound a maximum of 11.8 ng hLf. The dissociation constant of the interaction was 1.6 X 10(-7) …
Authors
Debanne MT; Regoeczi E; Sweeney GD; Krestynski F
Journal
American Journal of Physiology, Vol. 248, No. 4, pp. g463–g469
Publisher
American Physiological Society
Publication Date
April 1, 1985
DOI
10.1152/ajpgi.1985.248.4.g463
ISSN
0002-9513