Journal article
Macrophage Migration Inhibitory Factor Antagonist Blocks the Development of Endometriosis In Vivo
Abstract
Endometriosis, a disease of reproductive age women, is a major cause of infertility, menstrual disorders and pelvic pain. Little is known about its etiopathology, but chronic pelvic inflammation is a common feature in affected women. Beside symptomatic treatment of endometriosis-associated pain, only two main suboptimal therapeutic approaches (hormonal and invasive surgery) are generally recommended to patients and no specific targeted …
Authors
Khoufache K; Bazin S; Girard K; Guillemette J; Roy M-C; Verreault J-P; Al-Abed Y; Foster W; Akoum A
Journal
PLOS ONE, Vol. 7, No. 5,
Publisher
Public Library of Science (PLoS)
Publication Date
2012
DOI
10.1371/journal.pone.0037264
ISSN
1932-6203
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AnimalsCell AdhesionCyclooxygenase 2DNA PrimersEndometriosisFemaleGene Expression RegulationHistological TechniquesHumansIntegrin alphaVIntegrin beta3Interleukin-8Intramolecular OxidoreductasesIsoxazolesMacrophage Migration-Inhibitory FactorsMatrix Metalloproteinase 2Matrix Metalloproteinase 9MiceMice, NudeNeovascularization, PathologicReal-Time Polymerase Chain ReactionStatistics, NonparametricVascular Endothelial Growth Factor A