Journal article
Proportion of fetal hemoglobin synthesis decreases during erythroid cell maturation.
Abstract
Peripheral blood mononuclear cells from pregnant and postpartum women were cultured in vitro with erythropoietin. Burst-forming unit (BFU-E)-derived erythroid colonies composed of immature erythroblasts with low hemoglobin contents were observed by day 8 of culture. By day 12 of culture, numerous BFU-E-derived erythroid colonies with high hemoglobin contents were present. The gamma/(gamma + beta) globin synthetic ratio was approximately 12% in …
Authors
Chui DH; Wong SC; Enkin MW; Patterson M; Ives RA
Journal
Proceedings of the National Academy of Sciences of the United States of America, Vol. 77, No. 5, pp. 2757–2761
Publisher
Proceedings of the National Academy of Sciences
Publication Date
5 1980
DOI
10.1073/pnas.77.5.2757
ISSN
0027-8424