Self-Reported Mental Health Problems Among Adults Born Preterm: A Meta-analysis Academic Article uri icon

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  • CONTEXT: Preterm birth increases the risk for mental disorders in adulthood, yet findings on self-reported or subclinical mental health problems are mixed. OBJECTIVE: To study self-reported mental health problems among adults born preterm at very low birth weight (VLBW; ≤1500 g) compared with term controls in an individual participant data meta-analysis. DATA SOURCES: Adults Born Preterm International Collaboration. STUDY SELECTION: Studies that compared self-reported mental health problems using the Achenbach Young Adult Self Report or Adult Self Report between adults born preterm at VLBW (n = 747) and at term (n = 1512). DATA EXTRACTION: We obtained individual participant data from 6 study cohorts and compared preterm and control groups by mixed random coefficient linear and Tobit regression. RESULTS: Adults born preterm reported more internalizing (pooled β = .06; 95% confidence interval .01 to .11) and avoidant personality problems (.11; .05 to .17), and less externalizing (-.10; -.15 to -.06), rule breaking (-.10; -.15 to -.05), intrusive behavior (-.14; -.19 to -.09), and antisocial personality problems (-.09; -.14 to -.04) than controls. Group differences did not systematically vary by sex, intrauterine growth pattern, neurosensory impairments, or study cohort. LIMITATIONS: Exclusively self-reported data are not confirmed by alternative data sources. CONCLUSIONS: Self-reports of adults born preterm at VLBW reveal a heightened risk for internalizing problems and socially avoidant personality traits together with a lowered risk for externalizing problem types. Our findings support the view that preterm birth constitutes an early vulnerability factor with long-term consequences on the individual into adulthood.


  • Pyhälä, Riikka
  • Wolford, Elina
  • Kautiainen, Hannu
  • Andersson, Sture
  • Bartmann, Peter
  • Baumann, Nicole
  • Brubakk, Ann-Mari
  • Evensen, Kari Anne I
  • Hovi, Petteri
  • Kajantie, Eero
  • Lahti, Marius
  • Van Lieshout, Ryan
  • Saigal, Saroj
  • Schmidt, Louis
  • Indredavik, Marit S
  • Wolke, Dieter
  • Räikkönen, Katri

publication date

  • April 2017