Optimal Dose for Starting and Maintaining Low-Dose Aspirin

ANTITHROMBOTIC properties of aspirin were first proposed 25 years ago when aspirin was shown to inhibit platelet aggregation and to prolong bleeding time,1-5 but it is only in the past 10 years that the therapeutic benefit of aspirin's antithrombotic properties has been conclusively established by randomized controlled trials.6-14 Early studies used relatively large aspirin doses of approximately 1000 mg, but with increased understanding of the …