Journal article
Mitotic counts in breast cancer should be standardized with a uniform sample area
Abstract
BackgroundMitotic rate is routinely assessed in breast cancer cases and based on the assessment of 10 high power fields (HPF), a non-standard sample area, as per the College of American Pathologists cancer checklist. The effect of sample area variation has not been assessed.MethodsA computer model making use of the binomial distribution was developed to calculate the misclassification rate in 1,000,000 simulated breast specimens using the …
Authors
Bonert M; Tate AJ
Journal
BioMedical Engineering OnLine, Vol. 16, No. 1,
Publisher
Springer Nature
Publication Date
December 2017
DOI
10.1186/s12938-016-0301-z
ISSN
1475-925X