An experimental study was conducted to investigate damping and fluidelastic instability in tube arrays subjected to two-phase cross-flow. The purpose of this research was to improve our understanding of these phenomena and how they are affected by void fraction and flow regime. The working fluid used was Freon 11, which better models steam-water than air-water mixtures in terms of vapour-liquid mass ratio as well as permitting phase changes due to pressure fluctuations. The damping measurements were obtained by “plucking” the monitored tube from outside the test section using electromagnets. An exponential function was fitted to the tube decay trace, producing consistent damping measurements and minimizing the effect of frequency shifting due to fluid added mass fluctuations. The void fraction was measured using a gamma densitometer, introducing an improvement over the Homogeneous Equilibrium Model (HEM) in terms of density and velocity predictions. It was found that the Capillary number, when combined with the two-phase damping ratio (interfacial damping), shows a well defined behaviour depending on the flow regime. This observation can be used to develop a better methodology to normalize damping results. The fluidelastic results agree with previously presented data when analyzed using the HEM and the half-power bandwidth method. The interfacial velocity is suggested for fluidelastic studies due to its capability for collapsing the fluidelastic data. The interfacial damping was introduced as a tool to include the effects of flow regime into the stability maps.