Low-dose Aspirin and Cancer Mortality: A Meta-analysis of Randomized Trials

OBJECTIVE: Low-dose aspirin is a common strategy for preventing cardiovascular disease and associated mortality. A recent individual patient data meta-analysis of 8 trials of low- and high-dose aspirin, with long-term follow-up, found important reductions in cancer mortality. We aimed to determine whether cancer mortality also is reduced by low-dose aspirin in the shorter term. METHODS: We conducted a comprehensive search of 10 electronic …