Journal article
A users' guide to understanding therapeutic substitutions
Abstract
Therapeutic substitutions are common at the level of ministries of health, clinicians, and pharmacy dispensaries. Guidance in determining whether drugs offer similar risk-benefit profiles is limited. Those making decisions on therapeutic substitutions should be aware of potential biases that make differentiating therapeutic agents difficult. Readers should consider whether the biological mechanisms and doses are similar across agents, whether …
Authors
Mills EJ; Gardner D; Thorlund K; Briel M; Bryan S; Hutton B; Guyatt GH
Journal
Journal of Clinical Epidemiology, Vol. 67, No. 3, pp. 305–313
Publisher
Elsevier
Publication Date
3 2014
DOI
10.1016/j.jclinepi.2013.09.008
ISSN
0895-4356