Journal article
Facilitative glucose transporters: Implications for cancer detection, prognosis and treatment
Abstract
It is long recognized that cancer cells display increased glucose uptake and metabolism. In a rate-limiting step for glucose metabolism, the glucose transporter (GLUT) proteins facilitate glucose uptake across the plasma membrane. Fourteen members of the GLUT protein family have been identified in humans. This review describes the major characteristics of each member of the GLUT family and highlights evidence of abnormal expression in tumors …
Authors
Barron CC; Bilan PJ; Tsakiridis T; Tsiani E
Journal
Metabolism, Vol. 65, No. 2, pp. 124–139
Publisher
Elsevier
Publication Date
2 2016
DOI
10.1016/j.metabol.2015.10.007
ISSN
0026-0495