Journal article
Hippocampal metabolic abnormalities at first onset and with recurrent episodes of a major depressive disorder: A proton magnetic resonance spectroscopy study
Abstract
The neural underpinnings of major depressive disorder (MDD) are unknown but there is evidence for structural alteration in the hippocampus that may become more pronounced over the course of illness. The aim of the present study was to examine metabolite levels of N-acetyl-aspartate (NAA), Myo-inositol (MI), Glutamate-glutamine (Glx) and choline-containing compounds (GPC and GPC+PCh) in patients presenting for first treatment of a depressive …
Authors
Milne A; MacQueen GM; Yucel K; Soreni N; Hall GBC
Journal
NeuroImage, Vol. 47, No. 1, pp. 36–41
Publisher
Elsevier
Publication Date
August 2009
DOI
10.1016/j.neuroimage.2009.03.031
ISSN
1053-8119