Journal article
Detailed map of a cis-regulatory input function
Abstract
Most genes are regulated by multiple transcription factors that bind specific sites in DNA regulatory regions. These cis-regulatory regions perform a computation: the rate of transcription is a function of the active concentrations of each of the input transcription factors. Here, we used accurate gene expression measurements from living cell cultures, bearing GFP reporters, to map in detail the input function of the classic lacZYA operon of …
Authors
Setty Y; Mayo AE; Surette MG; Alon U
Journal
Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, No. 13, pp. 7702–7707
Publisher
Proceedings of the National Academy of Sciences
Publication Date
June 24, 2003
DOI
10.1073/pnas.1230759100
ISSN
0027-8424