Relationship between the per cent of marrow cells in S phase and the outcome of remission-induction therapy for acute nonlymphocytic leukaemia Academic Article uri icon

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abstract

  • The relationship between the pretherapy cell cycle characteristics of leukaemic marrow cells and the outcome of remission-induction therapy for acute nonlymphocytic leukaemia was studied in newly diagnosed and relapsed patients who were then treated with either combination chemotherapy consisting of cytosine arabinoside/anthracycline antibiotic +/- 6 thioguanine or with single agent high-dose cytosine arabinoside therapy. The outcome of high-dose cytosine arabinoside therapy was highly dependent upon the per cent of pretherapy cells in S phase with no remissions occurring in patients in whom the 3H-TdR labelling index was less than 6%. In contrast, the outcome of cytosine arabinoside/anthracycline antibiotic therapy was independent of the pretherapy cell cycle characteristics of the leukaemic cells.

authors

  • Preisler, HD
  • Azarnia, N
  • Raza, A
  • Grunwald, H
  • Vogler, R
  • Browman, George
  • Goldberg, J
  • Chervenick, P
  • Miller, K
  • Brennan, J
  • Winton, L
  • and, R Joyce
  • Gottlieb(Intergroup Leukemia Study), A

publication date

  • March 1984