Macrophage Function Disorders

Macrophages respond to alterations in their microenvironment by producing a wide variety of products that mediate inflammation, immunity and tissue homeostasis or injury. Macrophage recognize pathogen-associated molecular patterns (e.g. bacterial products) and endogenous ligands (e.g. apoptotic cells) through a broad and adaptable range of pattern-recognition receptors. The consequence of this recognition is generally effective clearance via …