Thrombotic thrombocytopenic purpura with myocardial ischaemia: two case reports.

Thrombotic thrombocytopenic purpura (TTP) is mainly perceived by cardiologists as a rare complication of ticlopidine or clopidogrel treatment. However, this life-threatening disease is provoked not only by antiplatelet drugs and may lead to myocardial ischaemia and necrosis caused by microvascular thrombosis and anaemia. We present two thienopiridine-naive patients who had acquired TTP and myocardial ischaemia, and were successfully treated by plasma exchanges.