Journal article
Alterations in Brain Metabolism Induced by Chronic Morphine Treatment: NMR Studies in Rat CNS
Abstract
High-resolution (500 MHz) multiresonance/multinuclear proton (1H) nuclear magnetic resonance (NMR) spectroscopy was used to detect metabolic changes and cellular injury in the rat brain stem and spinal cord following chronic morphine treatment. Compensatory changes were observed in glycine, glutamate, and inositols in the brain stem, but not the spinal cord, of chronic morphine-treated rats. In spinal cord, increases were detected in lactate …
Authors
Sharma SK; Yashpal K; Fundytus ME; Sauriol F; Henry JL; Coderre TJ
Journal
Neurochemical Research, Vol. 28, No. 9, pp. 1369–1373
Publisher
Springer Nature
Publication Date
9 2003
DOI
10.1023/a:1024996415795
ISSN
0364-3190