Effect of Vitamin A supplementation on the immune response to measles vaccination Academic Article uri icon

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abstract

  • A randomized controlled trial was conducted in 395 infants aged 9-12 months to determine the effect of Vitamin A supplementation on concurrently administered measles vaccine. Antibody response was measured using the plaque reduction neutralization assay. No statistically significant differences were demonstrated between the immune response in Vitamin A supplemented and unsupplemented children. Unlike some recent studies, we were unable to demonstrate an immune enhancing effect of Vitamin A supplementation. On the contrary, among children who were given Vitamin A, a lower, but statistically non-significant, proportion had protective antibody levels 6 months after vaccination.

authors

  • Cherian, Thomas
  • Varkki, Sneha
  • Raghupathy, P
  • Ratnam, Sam
  • Chandra, Ranjit K

publication date

  • June 2003