Therapeutic trial of cryofiltration in patients with rheumatoid arthritis Academic Article uri icon

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  • Cryofiltration, a new technique for on-line plasma separation and its treatment by cold filtration, enables the selective removal of immune complexes and eliminates the need for replacement proteins. Fifteen patients with rheumatoid arthritis were treated for nine to 10 consecutive sessions over a three- to five-week period. Circulating immune complexes decreased by an average of 78 percent and rheumatoid factor by 32 percent. This was accompanied by significant clinical improvement in morning stiffness, articular index, 50-foot walking time, grip strength, and target joint circumference. Cryofiltration might thus be beneficial for a subgroup of rheumatoid arthritis patients in whom conventional therapy has failed.


  • Krakauer, Randall S
  • Wysenbeek, Arjeh J
  • Wallace, Daniel J
  • Jones, John V
  • Smith, James
  • Malchesky, Paul
  • Greenstreet, Richard
  • Goldfinger, Dennis
  • Klinenberg, James R
  • McLeod, Bruce
  • Nose, Yukihiko

publication date

  • June 1983