Journal article
Partial expression of GP Ib measured by flow cytometry in two patients with Bernard-Soulier syndrome
Abstract
Bernard-Soulier syndrome is a rare, congenital bleeding disorder caused by absent or defective GP Ib platelet membrane receptor for the von Willebrand factor (vWF). We studied two brothers with moderate bleeding symptoms. Bleeding time was prolonged and ristocetin-induced platelet aggregation was absent. Flow cytometric analysis showed that both boys had a subnormal expression of GP Ib. One antibody used (AN51) was bound only to 30% of the …
Authors
Bunescu A; Lindahl T; Solum NO; Schulman S; Larsson A; Lundahl J; Egberg N
Journal
Thrombosis Research, Vol. 76, No. 5, pp. 441–450
Publisher
Elsevier
Publication Date
December 1994
DOI
10.1016/0049-3848(95)90176-g
ISSN
0049-3848