Journal article
Tumor Microsatellite-Instability Status as a Predictor of Benefit from Fluorouracil-Based Adjuvant Chemotherapy for Colon Cancer
Abstract
BACKGROUND: Colon cancers with high-frequency microsatellite instability have clinical and pathological features that distinguish them from microsatellite-stable tumors. We investigated the usefulness of microsatellite-instability status as a predictor of the benefit of adjuvant chemotherapy with fluorouracil in stage II and stage III colon cancer.
METHODS: Tumor specimens were collected from patients with colon cancer who were enrolled in …
Authors
Ribic CM; Sargent DJ; Moore MJ; Thibodeau SN; French AJ; Goldberg RM; Hamilton SR; Laurent-Puig P; Gryfe R; Shepherd LE
Journal
New England Journal of Medicine, Vol. 349, No. 3, pp. 247–257
Publisher
Massachusetts Medical Society
Publication Date
July 17, 2003
DOI
10.1056/nejmoa022289
ISSN
0028-4793