The rete mirabile of the eel: A useful model for the study of transcapillary passage of MR contrast agents Academic Article uri icon

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abstract

  • Our purpose was to study the capillary leakage of MR contrast media using a pure capillary model, the rete mirabile of the eel. The rete is a countercurrent-exchange organ composed of an arterial and a venous capillary system that can be catheterized and perfused. Substances are introduced at the arterial input by a constant infusion, and their steady-state concentrations are measured at the arterial and venous outputs. The capillary leakage of four MR contrast agents--Gd-DOTA(MW = 561 D), carboxymethyldextran-Gd-DTPA (MW = 38,900 D), albumin-Gd-DTPA (MW = 92,000 D), AMI-227 (400,000 D

authors

  • Siauve, Nathalie
  • Cu�nod, Charles-Andr
  • Cl�ment, Olivier
  • Rasio, Eugenio
  • Bendayan, Moise
  • Frija, Guy

publication date

  • February 1999