Journal article
Piecing Together the Humoral and Cellular Mechanisms of Immune Thrombocytopenia
Abstract
The precise mechanisms leading to platelet-targeted autoimmunity in immune thrombocytopenia (ITP) are not known. Cellular checkpoints normally regulate immunological self-reactivity during the development of B and T cells through cell deletion, receptor editing, induction of anergy, and extrinsic cellular suppression. When these checkpoints fail, tolerance to self-antigens may be lost. In this review, we summarize the various immune mechanisms …
Authors
Toltl L; Nazi I; Jafari R; Arnold D
Journal
Seminars in Thrombosis and Hemostasis, Vol. 37, No. 06, pp. 631–639
Publisher
Thieme
Publication Date
September 2011
DOI
10.1055/s-0031-1291373
ISSN
0094-6176